How do tricyclic antidepressants work What are Tricyclic Antidepressants?Tricyclic anti-depressants are sometimes used to treat and manage depression. Tricyclics work by interfering with neurotransmitter pathways in the body, affecting neurotransmitters such as serotonin, dopamine, and adrenaline. Tricyclic antidepressant (TCA) medications have been used since the 1950s to treat depression and bipolar disorder, as well as … Continue reading 10 Ways Tricyclic Antidepressants Can Help You